Biomedical Instrument Development Group
The team has obtained 16 patents for the development of biomedical devices.
In the course of scientific research, a new optical method to study the functional activity of platelets was developed and patented. This method formed the basis of a laser analyzer for the aggregation of platelets and other blood cells.
The created device "ALAT 230" is now widely used in many laboratories both in Russia and abroad. The electroencephalographs developed by the staff of the group have also found wide application in clinical practice. In addition to the creation of these devices, there have been developments in other areas of medicine, such as andrology and ophthalmology.
Currently, an integrated system for diagnosing regional neurogenic and circulatory status (together with neurovascular tone) of vital human organs is under development. This new non-invasive and reliable diagnosis based on new approaches to the method of harmonic analysis of bio-impedance is intended for clinical cardiology, urology, andrology, experimental physiology and surgery.
Bioengineering Chemistry Group
Head of the group - Professor Alexander V. Maksimenko
The main research direction is associated with study of pharmacological enzyme complex functioning with other low- and high- molecular compounds for elicitation and evaluation of therapeutic potential for such adsorbed or covalently coupled conjugates. The effects in systems in vitro and in vivo were investigated for supramolecular antioxidant derivative of superoxide dismutase-chondroitin sulfate-catalase, native and chondroitin sulfate modified hyaluronidase (from bovine testicles) for protection of vascular wall against injuries. The efficacious thrombolytic activity was demonstrated for modified forms of urokinase after its separate or joint intravenous administration including tissue plasminogen activator for destruction and removal of arterial thrombosis’s. The investigation of combined action of enzyme derivatives is performed for development of efficacious cures of enzymetherapy with aim of injurious effect blocking of oxidative stress and salt loading on blood circulation of organism. The modification of enzymes implies the use of well-grounded recommendations for targeted alteration of enzyme structures. Molecular docking of hyaluronidase with glycosaminoglycan components of endothelial glycocalyx is performed for straight forming of corresponding recommendations with help of computational chemistry methods in cooperation with gene engineering laboratory. At present the coupling and reaction of glycosaminoglycan ligands on protein structure is studied. Induced conformational transitions of enzyme structure herewith may stabilize the functioning of enzyme and ground the efficient recommendations for modification of biocatalysts with aim of obtaining of novel drug means and their efficacious therapeutic application.
Some recent publications:
• Maksimenko A.V. Results and achievements in the engineering of pharmacological enzymes for clinical application. Medical Research Archives, 2018, vol. 6, No. 1, p. 1-13. http://journals.ke-i.org/index.php/mra
• Maksimenko A.V., Beabealashvili R.S. Molecular docking of short-chain glycosaminoglycan ligands in 3D model of bovine testicular hyaluronidase. Current Research in Bioorganic and Organic Chemistry. 2018, vol. 2018, No. 2, 6 pages. CRBOC-111. Doi:10.29011/CRBOC-111.100011
• Maksimenko A.V. Vascular protection with antioxidant enzyme nanoderivative in conjugated via chondroitin sulfate form. Baltic Conference Series. International Conference on Nanomaterials & Nanotechnology (ICNANO) Drug Delivery & Nanomedicine (DD). Proceedings and Abstracts Book, P. 63-64, 09 – 12 October 2018. Stockholm, Sweden
• Maksimenko A.V. Translational research into vascular wall function: regulatory effects of systemic and specific factors. J. Transl. Sci., 2017, Vol. 3, 10 pages. Doi: 10.15761/JTS.1000179
• Maksimenko A.V. Widening and elaboration of consecutive research into therapeutic antioxidant enzyme derivatives. Oxidative Medicine and Cellular Longevity, 2016, vol. 2016, ID 3075695, http://dx.doi.org/10.1155/2016/3075695